Thursday, October 24, 2013

The sting backfires: Pain Exempt mouse eats Scorpion - NEWS

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 grasshopper mice are carnivores. This distinguishes them from most other rodents. grasshopper mice are carnivores. This distinguishes them from most other rodents (photo: picture alliance / dpa).

Thursday 24 October 2013

A scorpion sting can have distressing consequences which applies also in mice. Attacked the scorpion but a grasshopper mouse that carries not just in terms of deterrence. Its poison is different than it should. The painkillers research could benefit.

scorpion venom makes grasshopper mice insensitive to pain. This allows the mouse to attack and eat scorpions, even if they are like razor several times. This unique mechanism describes a group of U.S. researchers in the journal “Science”.

The team led by Ashlee Rowe of the University of Texas and Yucheng Xiao from Indiana University examined the impact of a domestic stitches, especially in North and Central America scorpion species (Centruroides spp.) on grasshopper mice and house mice. In house mice, scorpion venom causes severe pain. In the grasshopper mice, however, the toxin leads to a blockage of pain signals. This makes the mice temporarily largely insensitive to pain and allows them so to attack the scorpion.

unusual “symptoms of poisoning”

Rowe and her colleagues studied two common pain receptors in mammals with the name of Nav1.7 and Nav1.8 and so were the underlying mechanism. In the house mouse activates the scorpion venom Nav1.7. In the mouse, however, the toxin grasshopper reacts with certain amino acids of the receptor Nav1.8, then block the transmission of pain signals. Thus, the grasshopper mouse is not only insensitive to the scorpion venom, but against any kind of pain.

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  • In an accompanying commentary highlights Gary Lewin of the Max Delbrück Center for Molecular Medicine in Berlin, the possible significance of these results for the development of analgesics.

    grasshopper mice are native to North America and Mexico, and only distantly related to the house mouse. In contrast to most other rodents, they are carnivorous and feed on insects, scorpions, snake and small vertebrates.


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