Science - Medicine: Researchers Find in animal experiments possible approach to ... - Süddeutsche.de

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London / Berlin (dpa) – Researchers from Berlin and Graz have discovered a possible approach to dementia in animal studies: The food polyaminreicher food can therefore at least in fruit flies help to stop the age-related memory loss .

polyamines are important products of cell metabolism for tissue growth. Whether this approach would work in humans is still questionable and needs to be investigated in further studies.

“The concentration of endogenous polyamine spermidine increases with age in both flies and humans from,” explained Stephan Sigrist of the Freie Universität Berlin. In aging fruit flies that were fed with spermidine, the loss of memory could be slowed in experiments, write Sigrist and his colleague Frank Madeo (University of Graz) in a recent issue of the journal “Nature Neuroscience.”

In the study, the flies had to choose between two different odors, and remember that one of the odors with a negative result – a slight electric shock -. was connected

“One of the main suspects for the age-related dementia are clumped proteins that accumulate increased in old brains of flies, mice and humans,” says Sigrist. However, the body’s molecular cellular spermidine solvent from the cleaning process of autophagy. Acknowledges the cellular autophagy generally scrap among others, protein aggregates, and leads them to the cellular stomach (lysosomes) to. “This is an effect which is, interestingly, also known from fasting,” says Sigrist.

spermidine is produced by cells of the body itself, but it also occurs in the intestinal flora and is absorbed by food. High concentrations have about certain products or wheat seedlings from fermented soybeans (natto).

The researchers now hope to one day as a dietary supplement may be able to delay the onset of dementia in humans with spermidine. “Even a slight shift could be a big step for the individual patients and for society,” says Sigrist. “Until then, however, it is still a long way off.” Patient studies are now to follow.

published on 01.09.2013 at 13:48 clock